Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | USP2 | O75604 | 6/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654317 | 0.91 | MAP4K4 (0.61) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4170519 | 0.87 | CYP1A2 (0.52) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4187112 | 0.86 | MAP4K4 (0.60) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4184012 | 0.86 | MAP4K4 (0.65) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4167156 | 0.85 | MAP4K4 (0.64) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4184891 | 0.84 | MAP4K4 (0.60) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4190940 | 0.84 | MAP4K4 (0.57) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4170489 | 0.83 | MAP4K4 (0.59) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4178104 | 0.83 | CYP1A2 (0.61) | MAP4K4CLK4CYP1A2CYP3A4USP2 | |
| SCHEMBL4177167 | 0.83 | MAP4K4 (0.58) | MAP4K4CLK4CYP1A2CYP3A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996562-A1 | SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-12-03 | — | — | EP | claimed |
| WO-2007104560-A1 | SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-09-20 | — | — | WO | claimed |