Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.71 |
| ▸ | KIT | P10721 | 3/20 | 0.71 |
| ▸ | CDC7 | O00311 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | PRKACA | P17612 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431664 | 0.83 | CSF1R (1.00) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL1268018 | 0.83 | CSF1R (1.00) | CSF1RKITCDC7CDK2ROCK2 | |
| Hydrochloric Acid SCHEMBL29973836 | 0.82 | CSF1R (0.98) | CSF1RKITCDC7CDK2ROCK2 | |
| Hydrochloric Acid SCHEMBL20166201 | 0.82 | CSF1R (0.98) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL857484 | 0.79 | CSF1R (0.70) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL1268092 | 0.77 | CSF1R (0.65) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL1267463 | 0.77 | CSF1R (0.68) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL878837 | 0.77 | CSF1R (0.68) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL878781 | 0.77 | CSF1R (0.68) | CSF1RKITCDC7CDK2ROCK2 | |
| SCHEMBL857418 | 0.77 | CSF1R (0.65) | CSF1RKITCDC7CDK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885723-A2 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007013896-A2 | PYRROL (2,3-B) PYRIDINE DERIVATIVES PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-02-01 | — | — | WO | disclosed |