SCHEMBL4654897

SCHEMBL4654897

O=C(c1ccccc1)c1ccc2c(c1)SCC(=O)N2CCOc1ccc(CC(OCC(F)(F)F)C(=O)O)cc1

nearest known ligand 0.51

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.51
PPARA Q07869 16/20 0.51
PPARD Q03181 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4652742 0.94 PPARG (0.49) PPARGPPARAPPARD
SCHEMBL4884983 0.92 PPARG (0.47) PPARGPPARAPPARD
SCHEMBL4652824 0.91 PPARG (0.55) PPARGPPARAPPARD
SCHEMBL4652823 0.91 PPARG (0.55) PPARGPPARAPPARD
SCHEMBL4653924 0.90 PPARG (0.57) PPARGPPARAPPARD
SCHEMBL4652730 0.89 PPARG (0.66) PPARGPPARAPPARD
SCHEMBL4652728 0.89 PPARG (0.66) PPARGPPARAPPARD
SCHEMBL4654004 0.85 PPARG (0.51) PPARGPPARAPPARD
SCHEMBL4878369 0.84 PPARG (0.51) PPARGPPARAPPARD
SCHEMBL4652872 0.84 PPARG (0.49) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1844029-B1 NOVEL HETEROCYCLIC OXIME DERIVATIVES, METHOD FOR PREPARING SAME AND USE THEREOF AS HYPOGLYCAEMIC OR HYPOLIPIDEMIC AGENTS SERVIER LAB (FR) 2008-11-12 EP disclosed