Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | THPO | P40225 | 1/20 | 0.80 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.78 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.71 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455316 | 1.00 | MAPT (0.80) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4654954 | 1.00 | MAPT (0.80) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL336400 | 1.00 | MAPT (0.80) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7384519 | 1.00 | MAPT (0.80) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Iodide SCHEMBL8054093 | 0.99 | MAPT (0.78) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL6234505 | 0.99 | MAPT (0.78) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL4661058 | 0.99 | MAPT (0.78) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10464259 | 0.99 | MAPT (0.78) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10464261 | 0.99 | MAPT (0.78) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL4661068 | 0.99 | MAPT (0.78) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110283118-B | Preparation method of barnidipine key intermediate | 贵州医科大学 | 2022-05-17 | — | — | CN | claimed |
| EP-3168215-B1 | PROCESS FOR PREPARATION OF BARNIDIPINE | USV PRIVATE LTD (IN) | 2020-05-20 | — | — | EP | claimed |
| EP-3168215-A2 | PROCESS FOR PREPARATION OF BARNIDIPINE | USV Private Limited (IN) | 2017-05-17 | — | — | EP | claimed |
| JP-2275854-A | — | — | None | — | — | JP | disclosed |
| CN-108689904-B | Preparation method and application of chiral heterocyclic tertiary alcohol intermediate | 轩竹生物科技股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| CN-110283118-B | Preparation method of barnidipine key intermediate | 贵州医科大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-110283118-B | Preparation method of barnidipine key intermediate | 贵州医科大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-108430989-B | Process for preparing 1, 4-dihydropyridine-3, 5-dicarboxylate derivatives and intermediates | 轩竹生物科技有限公司 | 2021-10-08 | — | — | CN | disclosed |
| EP-3168215-B1 | PROCESS FOR PREPARATION OF BARNIDIPINE | USV PRIVATE LTD (IN) | 2020-05-20 | — | — | EP | disclosed |
| CN-110283118-A | Preparation method of barnidipine key intermediate | 贵州医科大学 | 2019-09-27 | — | — | CN | disclosed |
| EP-3168215-A2 | PROCESS FOR PREPARATION OF BARNIDIPINE | USV Private Limited (IN) | 2017-05-17 | — | — | EP | disclosed |
| US-5367081-A | Vasodilator, antiallergen | FUJIREBIO INC. (JP) | 1994-11-22 | — | — | US | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0488345-A1 | 1,4-Dihydropyridine derivatives and methods of producing the same | FUJIREBIO INC. (JP) | 1992-06-03 | — | — | EP | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |
| JP-H02275854-A | OPTICALLY ACTIVE DIHYDROPYRIDINE DERIVATIVE, PRODUCTION AND ITS USE | TAKEDA CHEM IND LTD | 1990-11-09 | — | — | JP | disclosed |
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |
| US-4616002-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1986-10-07 | — | — | US | disclosed |