Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 8/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652773 | 1.00 | IRAK4 (0.43) | IRAK4MKNK1MKNK2FLT3CDK2 | |
| Hydrochloric Acid SCHEMBL4117075 | 0.99 | IRAK4 (0.42) | IRAK4MKNK1MKNK2FLT3CDK2 | |
| Hydrochloric Acid SCHEMBL4117078 | 0.99 | IRAK4 (0.42) | IRAK4MKNK1MKNK2FLT3CDK2 | |
| SCHEMBL4118724 | 0.88 | CDK2 (0.35) | IRAK4MKNK1MKNK2FLT3CDK2 | |
| SCHEMBL4118711 | 0.88 | CDK2 (0.35) | IRAK4MKNK1MKNK2FLT3CDK2 | |
| SCHEMBL4652606 | 0.84 | MKNK1 (0.52) | IRAK4MKNK1MKNK2CDK2MAPK8 | |
| SCHEMBL4652609 | 0.84 | MKNK1 (0.52) | IRAK4MKNK1MKNK2CDK2MAPK8 | |
| Hydrochloric Acid SCHEMBL4117071 | 0.83 | MKNK1 (0.51) | IRAK4MKNK1MKNK2CDK2MAPK8 | |
| Hydrochloric Acid SCHEMBL4117079 | 0.83 | MKNK1 (0.51) | IRAK4MKNK1MKNK2CDK2MAPK8 | |
| SCHEMBL4654968 | 0.82 | IRAK4 (0.47) | IRAK4CDK2PDGFRAFGFR1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597258-B1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD THEREOF, APPLICATION OF SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | AVENTIS PHARMA SA (FR) | 2008-11-05 | — | — | EP | claimed |
| EP-1597258-A2 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD THEREOF, APPLICATION OF SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | Aventis Pharma S.A. (FR) | 2005-11-23 | — | — | EP | claimed |
| WO-2004073595-A2 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD THEREOF, APPLICATION OF SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | AVENTIS PHARMA S.A. (FR) | 2004-09-02 | — | — | WO | claimed |
| EP-1597258-B1 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD THEREOF, APPLICATION OF SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | AVENTIS PHARMA SA (FR) | 2008-11-05 | — | — | EP | disclosed |
| EP-1597258-A2 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD THEREOF, APPLICATION OF SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | Aventis Pharma S.A. (FR) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004073595-A2 | NOVEL PURINE DERIVATIVES, PREPARATION METHOD THEREOF, APPLICATION OF SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | AVENTIS PHARMA S.A. (FR) | 2004-09-02 | — | — | WO | disclosed |