Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.49 |
| ▸ | USP2 | O75604 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171855 | 0.88 | IRAK4 (0.53) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4187738 | 0.87 | CYP1A2 (0.59) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4175372 | 0.84 | IRAK4 (0.55) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4654450 | 0.84 | IRAK4 (0.49) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4173066 | 0.84 | IRAK4 (0.61) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4654418 | 0.83 | CLK4 (0.41) | USP2CYP1A2CYP3A4CLK4MAPK1 | |
| SCHEMBL13917321 | 0.83 | IRAK4 (0.57) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4177424 | 0.83 | IRAK4 (0.60) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4655430 | 0.83 | IRAK4 (0.48) | IRAK4USP2CYP1A2CYP3A4CLK4 | |
| SCHEMBL4183839 | 0.82 | IRAK4 (0.59) | IRAK4USP2CYP1A2CYP3A4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996562-A1 | SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104560-A1 | SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-09-20 | — | — | WO | disclosed |