SCHEMBL4655355

SCHEMBL4655355

CCCCC(=O)N(Cc1cc(-c2ccc3ncnc(NC(C)(C)C)c3c2)ccc1F)C1CC1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 14/20 0.41
CD38 P28907 1/20 0.40
USP2 O75604 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
CLK4 Q9HAZ1 2/20 0.39
PDPK1 O15530 1/20 0.39
LMNA P02545 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
CCRL2 O00421 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4185087 0.89 IRAK4 (0.53) IRAK4USP2CYP1A2CYP3A4CLK4
SCHEMBL4170443 0.88 IRAK4 (0.44) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4184788 0.88 IRAK4 (0.44) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4191270 0.88 IRAK4 (0.41) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4181491 0.87 IRAK4 (0.42) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4178119 0.87 IRAK4 (0.43) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4182596 0.87 IRAK4 (0.41) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4173323 0.86 IRAK4 (0.42) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4180757 0.85 IRAK4 (0.43) IRAK4CD38USP2CYP1A2CYP3A4
SCHEMBL4173806 0.84 CYP1A2 (0.45) IRAK4CD38USP2CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1996562-A1 SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-12-03 EP claimed
WO-2007104560-A1 SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-09-20 WO claimed
EP-1996562-A1 SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-12-03 EP disclosed
WO-2007104560-A1 SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-09-20 WO disclosed