Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 14/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579347 | 0.91 | ECE1 (0.51) | ECE1MAOBF10ABCB1PTGDR2 | |
| SCHEMBL4655386 | 0.89 | ECE1 (0.51) | ECE1MAOBF10PTGDR2PPARG | |
| SCHEMBL4655390 | 0.89 | MAOB (0.50) | ECE1MAOBABCB1PTGDR2PPARG | |
| SCHEMBL4655266 | 0.89 | ECE1 (0.56) | ECE1MAOBF10PTGDR2KDM4E | |
| SCHEMBL4655298 | 0.88 | ECE1 (0.49) | ECE1MAOBF10EPHX2PPARG | |
| SCHEMBL4655292 | 0.87 | MAOB (0.50) | ECE1MAOBF10PTGDR2EPHX2 | |
| SCHEMBL4655329 | 0.86 | ECE1 (0.49) | ECE1MAOBF10ABCB1EPHX2 | |
| SCHEMBL4655262 | 0.86 | ECE1 (0.51) | ECE1MAOBABCB1PPARG | |
| SCHEMBL4656151 | 0.86 | PPARG (0.49) | ECE1MAOBEPHX2PPARG | |
| SCHEMBL4655369 | 0.86 | ECE1 (0.49) | ECE1MAOBF10PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101010297-B | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS | 2011-07-27 | — | — | CN | claimed |
| EP-1776340-B1 | N-(1H-INDOLYL)-H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2008-12-03 | — | — | EP | claimed |