SCHEMBL4655378

SCHEMBL4655378

O=S(=O)(CCCCl)NCc1cccc(-c2ccc3ncnc(NC4CC4)c3c2)c1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 2/20 0.58
CYP1A2 P05177 13/20 0.56
CLK4 Q9HAZ1 11/20 0.56
CYP3A4 P08684 11/20 0.56
USP2 O75604 9/20 0.56
CYP2C19 P33261 9/20 0.56
LMNA P02545 6/20 0.56
MAPK1 P28482 5/20 0.56
CYP2D6 P10635 6/20 0.52
TSHR P16473 5/20 0.52
ALDH1A1 P00352 3/20 0.52
ALOX15 P16050 2/20 0.52
IRAK4 Q9NWZ3 5/20 0.49
HSD17B10 Q99714 4/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
KDM4E B2RXH2 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4178977 0.99 MAP4K4 (0.57) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4167156 0.82 MAP4K4 (0.64) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4655376 0.81 MAP4K4 (0.58) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4173751 0.81 MAP4K4 (0.67) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4178685 0.81 CYP1A2 (0.60) MAP4K4CYP1A2CLK4CYP3A4USP2
Hydrochloric Acid SCHEMBL4184458 0.81 MAP4K4 (0.57) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4176068 0.80 MAP4K4 (0.66) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4184012 0.79 MAP4K4 (0.65) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4654317 0.79 MAP4K4 (0.61) MAP4K4CYP1A2CLK4CYP3A4USP2
SCHEMBL4185455 0.79 CYP1A2 (0.57) MAP4K4CYP1A2CLK4CYP3A4USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1996562-A1 SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-12-03 EP claimed
WO-2007104560-A1 SUBSTITUTED 4-AMINO-QUINAZOLINE DERIVATIVES AS REGULATORS OF METABOTROPIC GLUTAMATE RECEPTORS AND THEIR USE FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-09-20 WO claimed