Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19328981 | 0.83 | PARP1 (0.48) | PARP1SMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL1144988 | 0.83 | KDM4E (0.50) | ALDH1A1KDM4ERECQLPPARGPSMD14 | |
| SCHEMBL4698376 | 0.78 | PRMT5 (0.45) | PARP1SMN1; SMN2ALDH1A1PRMT5WDR77 | |
| SCHEMBL4700074 | 0.76 | PARP1 (0.58) | PARP1SMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL21575767 | 0.76 | PRMT5 (0.64) | PARP1SMN1; SMN2ALDH1A1LMNAPRMT5 | |
| SCHEMBL2463004 | 0.75 | MAP2K4 (0.44) | PARP1ALDH1A1KDM4ERECQL | |
| SCHEMBL4055439 | 0.75 | PARP1 (0.42) | PARP1ALDH1A1LMNAKDM4ERECQL | |
| SCHEMBL2463881 | 0.75 | PARP1 (0.45) | PARP1ALDH1A1LMNAKDM4ERECQL | |
| SCHEMBL4698084 | 0.75 | MCHR1 (0.55) | PARP1LMNAMEN1NPC1RAB9A | |
| SCHEMBL4703510 | 0.74 | PARP1 (0.47) | PARP1SMN1; SMN2ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998777-A1 | METHODS OF INHIBITING BTK AND SYK PROTEIN KINASES | F. Hoffmann-La Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107469-A1 | METHODS OF INHIBITING BTK AND SYK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |