Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.61 |
| ▸ | PIM1 | P11309 | 4/20 | 0.56 |
| ▸ | GSK3A | P49840 | 3/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | AKT1 | P31749 | 2/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | NEK2 | P51955 | 1/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656887 | 0.92 | BRAF (0.75) | BRAFPIM1GSK3AMAPK13AKT1 | |
| SCHEMBL5624102 | 0.83 | BRAF (0.71) | BRAFPIM1GSK3AMAPK13AKT1 | |
| SCHEMBL4656339 | 0.81 | BRAF (0.76) | BRAFKDM4EALDH1A1 | |
| SCHEMBL4657229 | 0.79 | BRAF (0.77) | BRAFPIM1GSK3AMAPK13AKT1 | |
| SCHEMBL4657246 | 0.77 | BRAF (0.80) | BRAFGSK3AKDM4EEPHA2 | |
| SCHEMBL4761960 | 0.76 | BRAF (1.00) | BRAF | |
| SCHEMBL4656916 | 0.76 | BRAF (1.00) | BRAFPIM1MAPK13 | |
| SCHEMBL5795871 | 0.76 | PIM1 (0.61) | BRAFPIM1GSK3AMAPK13AKT1 | |
| SCHEMBL3161203 | 0.75 | KDM4E (0.72) | PIM1GSK3AMAPK13AKT1PIM3 | |
| SCHEMBL4656024 | 0.75 | BRAF (0.81) | BRAFPIM1GSK3AMAPK13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996594-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-12-03 | — | — | EP | claimed |
| WO-2007109093-A2 | PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-09-27 | — | — | WO | claimed |