Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 16/20 | 0.49 |
| ▸ | CHUK | O15111 | 2/20 | 0.49 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658296 | 0.93 | IKBKB (0.58) | IKBKBCHUKEPHA3NTRK1CDK8 | |
| SCHEMBL4658292 | 0.93 | IKBKB (0.58) | IKBKBCHUKEPHA3NTRK1CDK8 | |
| SCHEMBL4657014 | 0.84 | IKBKB (0.60) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL4657018 | 0.84 | IKBKB (0.60) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL6276879 | 0.84 | IKBKB (0.56) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL4658251 | 0.84 | IKBKB (0.56) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL6276881 | 0.84 | IKBKB (0.56) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL4658255 | 0.84 | IKBKB (0.56) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL4657865 | 0.84 | IKBKB (0.59) | IKBKBCHUKEPHA3NTRK1GAK | |
| SCHEMBL4657859 | 0.84 | IKBKB (0.59) | IKBKBCHUKEPHA3NTRK1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2008654-A1 | 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amides | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2008-12-31 | — | — | EP | disclosed |
| EP-1513516-B1 | SUBSTITUTED 3-AMINO-THIENO(2,3-b) PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES | BOEHRINGER INGELHEIM PHARMA (US) | 2008-12-03 | — | — | EP | disclosed |