Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657002 | 0.84 | SLC6A4 (0.49) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL4657801 | 0.79 | SLC6A4 (0.48) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL8691086 | 0.78 | MEN1 (0.40) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL8730096 | 0.74 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL3505719 | 0.74 | DPP4 (0.64) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL3505724 | 0.74 | DPP4 (0.64) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL3504324 | 0.74 | DPP4 (0.60) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL3507073 | 0.74 | DPP4 (0.60) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL4657207 | 0.74 | DPP4 (0.60) | SLC6A4SLC6A3SLC6A2CA1CA2 | |
| SCHEMBL3504330 | 0.74 | DPP4 (0.60) | SLC6A4SLC6A3SLC6A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999117-A2 | RENIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007117961-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-10-18 | — | — | WO | disclosed |