Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39159 | 0.89 | EGFR (0.70) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL29972560 | 0.89 | EGFR (0.70) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL30227615 | 0.88 | EGFR (0.69) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL25225907 | 0.88 | EGFR (0.69) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| Lithium SCHEMBL30227618 | 0.88 | EGFR (0.69) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL25255502 | 0.88 | EGFR (0.69) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL25255808 | 0.88 | EGFR (0.69) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| Potassium SCHEMBL30173582 | 0.88 | EGFR (0.69) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL15154102 | 0.84 | EGFR (0.64) | EGFRNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL15154326 | 0.83 | EGFR (0.59) | EGFRNPC1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006544-A1 | 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-01-12 | — | — | WO | disclosed |