Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 16/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 16/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 16/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 16/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 16/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 16/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 16/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478909 | 0.94 | HDAC3 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5478913 | 0.94 | HDAC3 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6855816 | 0.79 | AKT1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6855822 | 0.79 | AKT1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14430155 | 0.76 | HDAC3 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14430156 | 0.76 | HDAC3 (0.52) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14430216 | 0.75 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6853663 | 0.74 | AKT1 (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6853666 | 0.74 | AKT1 (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7109347 | 0.71 | AKT1 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720855-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1720855-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085227-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |