Sugi Predict

Sugi Predict / Compounds / SCHEMBL4659848

SCHEMBL4659848

SCHEMBL4659848

Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4ccc(Cl)c(Cl)c4)cnc3-c3ccccc3)cc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AKT1 P31749 19/20 0.63
▸ ROCK1 Q13464 8/20 0.57
▸ CSNK1A1 P48729 2/20 0.55
▸ CSNK1D P48730 2/20 0.55
▸ CDC7 O00311 1/20 0.55
▸ EEF2K O00418 1/20 0.55
▸ PLK4 O00444 1/20 0.55
▸ CHEK1 O14757 1/20 0.55
▸ AURKA O14965 1/20 0.55
▸ DCLK1 O15075 1/20 0.55
▸ MAPK13 O15264 1/20 0.55
▸ PDPK1 O15530 1/20 0.55
▸ DAPK3 O43293 1/20 0.55
▸ DYRK3 O43781 1/20 0.55
▸ RPS6KA5 O75582 1/20 0.55
▸ PRKD3 O94806 1/20 0.55
▸ PAK4 O96013 1/20 0.55
▸ CHEK2 O96017 1/20 0.55
▸ PRKCG P05129 1/20 0.55
▸ INSR P06213 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4658643 0.91 AKT1 (0.75) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4659976 0.90 AKT1 (0.65) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4659423 0.89 AKT1 (0.68) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL6849801 0.89 AKT1 (0.59) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4660669 0.88 AKT1 (0.71) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4660636 0.87 AKT1 (0.70) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4719556 0.87 AKT1 (0.65) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4658518 0.87 AKT1 (0.62) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4722826 0.86 AKT1 (0.77) AKT1ROCK1CSNK1A1CSNK1DCDC7
SCHEMBL4722830 0.86 AKT1 (0.77) AKT1ROCK1CSNK1A1CSNK1DCDC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720855-A4 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORP (US) 2008-12-17 — — EP claimed
US-20070185152-A1 Inhibitors of akt activity SMITHKLINE BEECHAM CORPORATION 2007-08-09 — — US claimed
EP-1720855-A1 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORPORATION (US) 2006-11-15 — — EP claimed
WO-2005085227-A1 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORPORATION (US) 2005-09-15 — — WO claimed
EP-1720855-A4 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORP (US) 2008-12-17 — — EP disclosed
US-20070185152-A1 Inhibitors of akt activity SMITHKLINE BEECHAM CORPORATION 2007-08-09 — — US disclosed
EP-1720855-A1 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORPORATION (US) 2006-11-15 — — EP disclosed
WO-2005085227-A1 INHIBITORS OF AKT ACTIVITY SMITHKLINE BEECHAM CORPORATION (US) 2005-09-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070185152-A1 Inhibitors of akt activity AKT1, AKT1S1, AKT2 AKT1 1/4885ROCK1 589/4885CSNK1A1 545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.