Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471035 | 0.94 | AKT1 (0.38) | AKT1JAK2ROCK1AAK1HDAC3 | |
| SCHEMBL4659872 | 0.94 | AKT1 (0.38) | AKT1JAK2ROCK1AAK1HDAC3 | |
| SCHEMBL14430124 | 0.86 | AKT1 (0.43) | AKT1JAK2ROCK1HDAC3HDAC4 | |
| SCHEMBL5470575 | 0.86 | AKT1 (0.36) | AKT1JAK2ROCK1AAK1HDAC3 | |
| SCHEMBL14430130 | 0.81 | AKT1 (0.42) | AKT1ROCK1HDAC3HDAC4HDAC1 | |
| SCHEMBL14430184 | 0.80 | AKT1 (0.44) | AKT1ROCK1FGFR1FGFR2FGFR3 | |
| SCHEMBL14430132 | 0.79 | AKT1 (0.39) | AKT1ROCK1HDAC3HDAC4HDAC1 | |
| SCHEMBL14430150 | 0.79 | AKT1 (0.41) | AKT1JAK2ROCK1HDAC3HDAC4 | |
| SCHEMBL14430147 | 0.79 | AKT1 (0.43) | AKT1JAK2ROCK1HDAC3HDAC4 | |
| SCHEMBL14430131 | 0.79 | AKT1 (0.38) | AKT1ROCK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720855-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1720855-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085227-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |