Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4662659 | 1.00 | ESR1 (0.53) | ESR1ESR2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4135203 | 0.91 | ESR1 (0.54) | ESR1ESR2MEN1KMT2AL3MBTL1 | |
| SCHEMBL13938655 | 0.91 | ESR1 (0.54) | ESR1ESR2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4660190 | 0.89 | ESR1 (0.48) | ESR1ESR2MEN1KMT2ACTSS | |
| SCHEMBL4660073 | 0.87 | ESR1 (0.41) | ESR1ESR2MEN1KMT2ACTSS | |
| SCHEMBL4661381 | 0.87 | ESR1 (0.41) | ESR1ESR2MEN1KMT2ACTSS | |
| SCHEMBL6406635 | 0.87 | ESR1 (0.55) | ESR1ESR2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4659967 | 0.87 | ESR1 (0.55) | ESR1ESR2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4661442 | 0.87 | ESR1 (0.55) | ESR1ESR2MEN1KMT2AL3MBTL1 | |
| SCHEMBL4661506 | 0.87 | ESR1 (0.55) | ESR1ESR2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620102-B1 | 3-(1-NAPHTHYL)-2-CYANOPROPANOIC ACID DERIVATIVES AS ESTROGEN RECEPTOR LIGANDS | WYETH CORP (US) | 2008-12-24 | — | — | EP | claimed |