SCHEMBL4662865

SCHEMBL4662865

CC1NC(Cc2ccc(Br)c(Oc3cc(Cl)cc(C#N)c3)c2F)=NNC1=O

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.60
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
KCNH2 Q12809 2/20 0.38
VEGFA P15692 1/20 0.30
EPAS1 Q99814 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4662860 1.00 CYP3A4 (0.60) CYP3A4CYP2C9CYP2C19KCNH2VEGFA
SCHEMBL4379310 0.91 CYP3A4 (0.72) CYP3A4CYP2C9CYP2C19KCNH2VEGFA
SCHEMBL13581455 0.91 CYP3A4 (0.72) CYP3A4CYP2C9CYP2C19KCNH2VEGFA
SCHEMBL4371404 0.91 CYP3A4 (0.72) CYP3A4CYP2C9CYP2C19KCNH2VEGFA
SCHEMBL13586650 0.90 CYP3A4 (0.60) CYP3A4CYP2C9CYP2C19KCNH2VEGFA
SCHEMBL14546142 0.90 CYP3A4 (0.60) CYP3A4CYP2C9CYP2C19KCNH2VEGFA
SCHEMBL4379876 0.88 CYP3A4 (0.49) CYP3A4CYP2C9CYP2C19VEGFAEPAS1
SCHEMBL4379873 0.88 CYP3A4 (0.49) CYP3A4CYP2C9CYP2C19VEGFAEPAS1
SCHEMBL14547411 0.87 CYP3A4 (0.65) CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL4374824 0.87 CYP3A4 (0.65) CYP3A4CYP2C9CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1937651-B1 NNRT INHIBITORS HOFFMANN LA ROCHE (CH) 2008-12-24 EP claimed
EP-1937651-A1 NNRT INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2008-07-02 EP claimed
WO-2007039463-A1 NNRT INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2007-04-12 WO claimed
EP-1937651-B1 NNRT INHIBITORS HOFFMANN LA ROCHE (CH) 2008-12-24 EP disclosed