Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL4665756 | 0.96 | JAK1 (0.43) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| Formic Acid SCHEMBL4664337 | 0.92 | ABL1 (0.42) | PIK3CAPIK3R1PIK3CBPIK3CGJAK1 | |
| Formic Acid SCHEMBL4663746 | 0.91 | PIK3CA (0.48) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| Formic Acid SCHEMBL4666178 | 0.88 | ABL1 (0.44) | JAK1JAK3JAK2BACE1MAPK13 | |
| Formic Acid SCHEMBL4663884 | 0.87 | ABL1 (0.43) | PIK3CAPIK3R1PIK3CBPIK3CGJAK1 | |
| SCHEMBL4666158 | 0.87 | ABL1 (0.46) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| Formic Acid SCHEMBL4666123 | 0.86 | EGFR (0.44) | JAK1JAK3JAK2BACE1ABL1 | |
| SCHEMBL4664279 | 0.84 | MEN1 (0.39) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| Formic Acid SCHEMBL4665657 | 0.84 | KMT2A (0.48) | JAK1JAK3JAK2BACE1ABL1 | |
| Formic Acid SCHEMBL4663842 | 0.84 | HRH3 (0.46) | PIK3CAPIK3R1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | ALTANA PHARMA AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | MAP3K19, MAP3K6, MAP3K20 | PIK3CA 161/4885PIK3R1 385/4885PIK3CD 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.