Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.77 |
| ▸ | LIFR | P42702 | 3/20 | 0.60 |
| ▸ | PPARD | Q03181 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422361 | 0.92 | NR1H4 (0.72) | NR1H4LIFRPPARD | |
| SCHEMBL4427551 | 0.92 | NR1H4 (0.77) | NR1H4LIFRPPARD | |
| SCHEMBL4433129 | 0.91 | NR1H4 (0.75) | NR1H4LIFRPPARD | |
| SCHEMBL2129752 | 0.91 | NR1H4 (0.65) | NR1H4LIFR | |
| SCHEMBL4831076 | 0.89 | NR1H4 (0.70) | NR1H4LIFR | |
| SCHEMBL28530824 | 0.88 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL4425112 | 0.85 | NR1H4 (0.72) | NR1H4LIFR | |
| SCHEMBL4831057 | 0.85 | NR1H4 (0.80) | NR1H4LIFRPPARD | |
| SCHEMBL28529145 | 0.84 | NR1H4 (1.00) | NR1H4LIFRPPARD | |
| SCHEMBL4665677 | 0.84 | NR1H4 (0.78) | NR1H4LIFRPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1877067-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| US-7319109-B2 | Farnesoid X receptor agonists | SMITH KLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319109-B2 | Farnesoid X receptor agonists | SMITH KLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| WO-2006116499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | MICROBIA, INC. (US) | 2006-11-02 | — | — | WO | disclosed |