Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | CIT | O14578 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 2/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | STK17B | O94768 | 2/20 | 0.39 |
| ▸ | STK10 | O94804 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | HCK | P08631 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665661 | 0.89 | BACE1 (0.42) | EGFRTNIKSRCABL1KDR | |
| SCHEMBL4666183 | 0.88 | ABL1 (0.42) | EGFRERBB2TNIKABL1BACE1 | |
| SCHEMBL4664341 | 0.88 | ABL1 (0.41) | EGFRTNIKABL1BACE1MAPK14 | |
| SCHEMBL4664279 | 0.87 | MEN1 (0.39) | EGFRTNIKABL1BACE1MAPK14 | |
| Formic Acid SCHEMBL4666123 | 0.84 | EGFR (0.44) | EGFRERBB2TNIKKITABL1 | |
| SCHEMBL4663739 | 0.84 | TNIK (0.41) | TNIKABL1KDRBACE1BCR | |
| SCHEMBL4663837 | 0.84 | AXL (0.45) | EGFRSRCABL1AXLHRH3 | |
| SCHEMBL4663887 | 0.84 | ABL1 (0.41) | EGFRTNIKABL1MAPK10BACE1 | |
| SCHEMBL4665758 | 0.83 | MEN1 (0.40) | EGFRTNIKABL1BACE1MAPK14 | |
| SCHEMBL4667537 | 0.83 | EGFR (0.41) | EGFRERBB2SRCABL1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | ALTANA PHARMA AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242681-A1 | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors | MAP3K19, MAP3K6, MAP3K20 | EGFR 279/4885ERBB2 39/4885TNIK 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.