Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.55 |
| ▸ | RARA | P10276 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107734 | 0.87 | GCK (0.57) | GCKRARARARBRARG | |
| SCHEMBL12603057 | 0.87 | GCK (0.61) | GCKRARARARBRARG | |
| SCHEMBL1107704 | 0.85 | GCK (0.68) | GCKRARARARBRARG | |
| SCHEMBL1107456 | 0.85 | GCK (0.68) | GCKRARARARBRARG | |
| SCHEMBL2085174 | 0.85 | GCK (0.68) | GCKRARARARBRARG | |
| SCHEMBL1107730 | 0.85 | GCK (0.68) | GCKRARARARBRARG | |
| SCHEMBL16270273 | 0.83 | GCK (0.57) | GCKRARARARBRARG | |
| SCHEMBL1107709 | 0.83 | GCK (0.55) | GCKRARARARBRARG | |
| SCHEMBL1107706 | 0.83 | GCK (0.63) | GCKRARARARBRARG | |
| SCHEMBL7935638 | 0.82 | GCK (0.83) | GCKRARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1992623-A1 | Heteroaryl benzamide derivative for use as GLK activator in the treatment of diabetes | Astra Zeneca AB (SE) | 2008-11-19 | — | — | EP | disclosed |