Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 15/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667819 | 0.87 | CHRM1 (0.47) | CHRM1CHRM4CHRM5 | |
| Iodide SCHEMBL4668691 | 0.78 | GFER (0.49) | GFERHSD17B10MTNR1AMTNR1BCNR1 | |
| SCHEMBL3130545 | 0.76 | MC4R (0.49) | CHRM1 | |
| SCHEMBL3140407 | 0.75 | CHRM1 (0.52) | CHRM1CHRM4CHRM5 | |
| SCHEMBL3139752 | 0.74 | CHRM1 (0.48) | CHRM1CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL4669744 | 0.73 | MC4R (0.36) | GFERHSD17B10 | |
| Hydrochloric Acid SCHEMBL4669743 | 0.72 | MC4R (0.48) | — | |
| SCHEMBL12896413 | 0.68 | CHRM1 (0.48) | CHRM1CHRM4CHRM5 | |
| SCHEMBL2148100 | 0.67 | CHRM1 (1.00) | CHRM1CHRM4CHRM5 | |
| SCHEMBL2287108 | 0.65 | CHRM1 (0.80) | CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1610789-A4 | BICYCLIC PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO INC (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1610789-A1 | BICYCLIC PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087159-A1 | BICYCLIC PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2004-10-14 | — | — | WO | disclosed |