Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 20/20 | 0.78 |
| ▸ | TACR2 | P21452 | 8/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996320 | 0.89 | TACR3 (0.62) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6447410 | 0.88 | TACR3 (1.00) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6452173 | 0.88 | TACR3 (1.00) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6447403 | 0.88 | TACR3 (1.00) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13995504 | 0.87 | TACR3 (0.78) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4665578 | 0.87 | TACR3 (0.77) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4667324 | 0.85 | TACR3 (0.74) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4668724 | 0.85 | TACR3 (0.74) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4665600 | 0.85 | TACR3 (0.65) | TACR3TACR2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8190142 | 0.84 | TACR3 (0.78) | TACR3TACR2CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306110-A1 | Alkylnitrile Quinolines as Nk-3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | claimed |
| EP-1928834-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-06-11 | — | — | EP | claimed |
| WO-2007035157-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |
| US-20080306110-A1 | Alkylnitrile Quinolines as Nk-3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306110-A1 | Alkylnitrile Quinolines as Nk-3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306110-A1 | Alkylnitrile Quinolines as Nk-3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| EP-1928834-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007035157-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035157-A1 | ALKYLNITRILE QUINOLINES, AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306110-A1 | Alkylnitrile Quinolines as Nk-3 Receptor Ligands | KCNQ3, TACR2, TACR3 | TACR3 3/4885TACR2 2/4885CYP1A2 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.