Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | CTSD | P07339 | 14/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667990 | 0.82 | BACE1 (0.48) | BACE1CTSDBACE2 | |
| SCHEMBL3357117 | 0.80 | BACE1 (0.48) | BACE1CTSDBACE2 | |
| SCHEMBL3357121 | 0.80 | BACE1 (0.48) | BACE1CTSDBACE2 | |
| Hydrochloric Acid SCHEMBL6706921 | 0.78 | BACE1 (0.47) | BACE1CTSDBACE2 | |
| SCHEMBL13307644 | 0.76 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL5223745 | 0.74 | BACE1 (0.49) | BACE1CTSDBACE2 | |
| SCHEMBL5223758 | 0.74 | BACE1 (0.49) | BACE1CTSDBACE2 | |
| SCHEMBL6571587 | 0.70 | BACE1 (0.51) | BACE1CTSDBACE2 | |
| SCHEMBL5369028 | 0.70 | BACE1 (0.40) | BACE1CTSDBACE2 | |
| Hydrochloric Acid SCHEMBL6706923 | 0.70 | BACE1 (0.51) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395551-B1 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND SIMILAR DISEASES | ELAN PHARM INC (US) | 2008-05-21 | — | — | EP | claimed |