Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.55 |
| ▸ | RARG | P13631 | 14/20 | 0.55 |
| ▸ | RARA | P10276 | 12/20 | 0.55 |
| ▸ | RXRA | P19793 | 14/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | RXRG | P48443 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668050 | 1.00 | RARB (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL4666453 | 0.85 | RARB (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL4666458 | 0.85 | RARB (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL4668045 | 0.84 | RARB (0.57) | RARBRARGRARARXRARXRB | |
| SCHEMBL4668042 | 0.84 | RARB (0.57) | RARBRARGRARARXRARXRB | |
| SCHEMBL4668060 | 0.83 | RARB (0.53) | RARBRARGRARARXRARXRB | |
| SCHEMBL4668059 | 0.83 | RARB (0.53) | RARBRARGRARARXRARXRB | |
| SCHEMBL4669339 | 0.83 | RARB (0.58) | RARBRARGRARARXRARXRB | |
| SCHEMBL4666918 | 0.83 | RARB (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL4669347 | 0.83 | RARB (0.58) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324970-B1 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |