Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.69 |
| ▸ | FLT1 | P17948 | 8/20 | 0.69 |
| ▸ | FLT4 | P35916 | 8/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.69 |
| ▸ | KIT | P10721 | 1/20 | 0.69 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668970 | 0.88 | KDR (0.67) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL4670216 | 0.86 | KDR (0.77) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL4668993 | 0.86 | KDR (0.67) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL5205672 | 0.86 | KDR (0.78) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL4669692 | 0.85 | KDR (0.66) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL5202078 | 0.85 | KDR (0.75) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL4668940 | 0.84 | KDR (0.63) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL5649349 | 0.84 | BRAF (0.79) | KDRBRAF | |
| SCHEMBL5205625 | 0.83 | KDR (0.86) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL13613040 | 0.83 | KDR (0.63) | KDRFLT1FLT4PDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652847-B1 | Quinoline and quinazoline derivatives for the treatment of tumors | KIRIN PHARMA KK (JP) | 2008-05-28 | — | — | EP | claimed |
| EP-1652847-A1 | Quinoline and quinazoline derivatives for the treatment of tumors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-05-03 | — | — | EP | claimed |
| EP-1652847-B1 | Quinoline and quinazoline derivatives for the treatment of tumors | KIRIN PHARMA KK (JP) | 2008-05-28 | — | — | EP | disclosed |
| US-7211587-B2 | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BEER KABUSHIKI KAISHA (KR) | 2007-05-01 | — | — | US | disclosed |
| EP-1652847-A1 | Quinoline and quinazoline derivatives for the treatment of tumors | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6821987-B2 | 4-SUBSTITUTED BY AZOLYLUREIDO-PHENOXY, OR PHENYLTHIO; ANTITUMOR AGENTS; TREATING DIABETIC RETINOPATHY, CHRONIC RHEUMATISM, PSORIASIS, ATHEROSCLEROSIS, | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-11-23 | — | — | US | disclosed |
| US-20040229876-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-11-18 | — | — | US | disclosed |
| EP-1382604-A1 | QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-01-21 | — | — | EP | disclosed |
| US-20030087907-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | KIRIN BEER KABUSHIKI KAISHA (JP) | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229876-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | NQO2, H1-5, NRAS | KDR 3455/4885FLT1 2511/4885FLT4 1955/4885 |
| US-20030087907-A1 | Quinoline derivatives and quinazoline derivatives having azolyl group | NQO2, H1-5, NRAS | KDR 3455/4885FLT1 2511/4885FLT4 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.