Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580081 | 0.87 | HDAC1 (0.82) | HDAC1HDAC2HDAC3HDAC8KCNH2 | |
| SCHEMBL1066960 | 0.85 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8KCNH2 | |
| SCHEMBL2684970 | 0.83 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC8KCNH2 | |
| SCHEMBL14781038 | 0.83 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC8KCNH2 | |
| SCHEMBL2684365 | 0.83 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC8KCNH2 | |
| SCHEMBL13833519 | 0.83 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL30118374 | 0.83 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL4582004 | 0.82 | HDAC1 (0.79) | HDAC1HDAC2HDAC3HDAC8KCNH2 | |
| SCHEMBL2208673 | 0.82 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL5547973 | 0.82 | HDAC1 (0.73) | HDAC1HDAC2HDAC3HDAC8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-A2 | INHIBITORS OF HISTONE DEACETYLASE | Merck & Co., Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007100657-A2 | INHIBITORS OF HISTONE DEACETYLASE | MERCK & CO., INC. (US) | 2007-09-07 | — | — | WO | disclosed |