Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.64 |
| ▸ | MERTK | Q12866 | 9/20 | 0.43 |
| ▸ | AXL | P30530 | 7/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591350 | 1.00 | ADORA2A (0.64) | ADORA2AADORA3MERTKAXLMET | |
| SCHEMBL3257520 | 1.00 | ADORA2A (0.64) | ADORA2AADORA3MERTKAXLMET | |
| SCHEMBL589606 | 1.00 | ADORA2A (0.64) | ADORA2AADORA3MERTKAXLMET | |
| SCHEMBL590519 | 1.00 | ADORA2A (0.64) | ADORA2AADORA3MERTKAXLMET | |
| SCHEMBL589607 | 1.00 | ADORA2A (0.64) | ADORA2AADORA3MERTKAXLMET | |
| SCHEMBL4367305 | 0.84 | ADORA2A (0.60) | ADORA2AADORA3 | |
| SCHEMBL590421 | 0.84 | ADORA2A (0.60) | ADORA2AADORA3 | |
| Trifluoroacetic Acid SCHEMBL588605 | 0.80 | ADORA2A (0.57) | ADORA2AADORA3ADORA1 | |
| SCHEMBL591104 | 0.78 | ADORA2A (1.00) | ADORA2AADORA3ADORA1 | |
| Trifluoroacetic Acid SCHEMBL589376 | 0.77 | ADORA2A (0.68) | ADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841768-B1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2008-11-12 | — | — | EP | disclosed |