Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12187772 | 0.84 | FUCA1 (0.55) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| SCHEMBL60509 | 0.84 | FUCA1 (0.55) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| SCHEMBL5540770 | 0.83 | FUCA1 (0.50) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| Hydrochloric Acid SCHEMBL11836687 | 0.82 | FUCA1 (0.53) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| SCHEMBL5316198 | 0.81 | DRD4 (0.50) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| SCHEMBL3315165 | 0.80 | FUCA1 (0.51) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| SCHEMBL1618174 | 0.79 | FUCA1 (0.50) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| SCHEMBL2968146 | 0.79 | S1PR5 (0.51) | FUCA1S1PR1S1PR5GBA1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1619305 | 0.78 | FUCA1 (0.49) | FUCA1SIGMAR1DRD4S1PR1S1PR5 | |
| Hydrochloric Acid SCHEMBL2966846 | 0.78 | S1PR5 (0.50) | FUCA1S1PR1S1PR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | claimed |
| EP-1765832-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123748-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |