Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453330 | 0.84 | PDE4B (0.64) | KDM4EHSD11B1PDE4BPDE4APDE4C | |
| SCHEMBL3452263 | 0.73 | PDE4B (0.53) | KDM4EPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2324279 | 0.73 | PDE4B (0.69) | KDM4EPDE4BKMT2ATSHRCYP2C9 | |
| SCHEMBL2327729 | 0.71 | PDE4B (0.60) | KDM4EPDE4B | |
| SCHEMBL2327263 | 0.71 | PDE4B (0.48) | KDM4EPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3453216 | 0.70 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2328052 | 0.68 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2324447 | 0.68 | PDE4B (0.64) | PDE4BKMT2ATSHRCYP2C9CYP2C19 | |
| SCHEMBL14251185 | 0.67 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2324278 | 0.67 | PDE4B (0.45) | KDM4EPDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |