Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CXCR6 | O00574 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 2/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669902 | 1.00 | MAPT (0.52) | MAPTMAPK1CCR2LTA4HMEN1 | |
| SCHEMBL3870275 | 0.98 | MAPT (0.51) | MAPTMAPK1CCR2LTA4HMEN1 | |
| SCHEMBL3870270 | 0.98 | MAPT (0.51) | MAPTMAPK1CCR2LTA4HMEN1 | |
| SCHEMBL3874225 | 0.92 | MAPT (0.57) | MAPTMAPK1LTA4HMEN1KMT2A | |
| SCHEMBL3874227 | 0.92 | MAPT (0.57) | MAPTMAPK1LTA4HMEN1KMT2A | |
| SCHEMBL3871796 | 0.86 | MAPT (0.52) | MAPTMAPK1CCR2MEN1KMT2A | |
| SCHEMBL3871794 | 0.86 | MAPT (0.52) | MAPTMAPK1CCR2MEN1KMT2A | |
| SCHEMBL3872987 | 0.85 | MAPT (0.53) | MAPTMAPK1LTA4HMEN1KMT2A | |
| SCHEMBL3880997 | 0.85 | MAPT (0.53) | MAPTMAPK1LTA4HMEN1KMT2A | |
| SCHEMBL3872069 | 0.83 | EPHX2 (0.60) | MAPTMAPK1MEN1KMT2ACXCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891064-A1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | Laboratorios Almirall, S.A. (ES) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133802-A1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-12-21 | — | — | WO | disclosed |