Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenofibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 7/20 | 1.00 |
| ▸ | CNR1 | P21554 | 6/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenofibrate SCHEMBL3876232 | 1.00 | PPARA (1.00) | PPARACNR1CYP1A2CYP3A4PPARG | |
| Fenofibrate SCHEMBL29262792 | 0.99 | PPARA (0.97) | PPARACNR1CYP1A2CYP3A4PPARG | |
| Fenofibrate SCHEMBL21758490 | 0.99 | PPARA (0.97) | PPARACNR1CYP1A2CYP3A4PPARG | |
| Fenofibrate SCHEMBL29262793 | 0.99 | PPARA (0.97) | PPARACNR1CYP1A2CYP3A4PPARG | |
| Fenofibrate SCHEMBL27847067 | 0.99 | PPARA (0.97) | PPARACNR1CYP1A2CYP3A4PPARG | |
| Fenofibrate SCHEMBL22209064 | 0.99 | PPARA (0.97) | PPARACNR1CYP1A2CYP3A4PPARG | |
| SCHEMBL31084128 | 0.96 | PPARA (0.92) | PPARACNR1CYP1A2CYP3A4PPARG | |
| SCHEMBL31084127 | 0.96 | PPARA (0.92) | PPARACNR1CYP1A2CYP3A4PPARG | |
| SCHEMBL21992457 | 0.93 | CNR1 (0.86) | PPARACNR1CYP1A2CYP3A4PPARG | |
| Fenofibrate SCHEMBL4251589 | 0.92 | PPARA (0.85) | PPARACNR1CYP1A2CYP3A4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 48416 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260145617-A1 | VEHICLE CARGO RESTRAINT SYSTEM | Primacy Solutions, LLC (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144756-A1 | A FENOFIBRATE COMPOSITION COMPRISING WATER SOLUBLE CHEMICALS AND A METHOD OF PRODUCTION THEREOF | US NANO FOOD AND DRUG INC (US) | 2026-05-28 | — | — | US | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-20260130342-A1 | Choke-Less Animal Harness Device | GAUSE CHARLES (US) | 2026-05-14 | — | — | US | claimed |
| US-12623814-B2 | Liquid pouring apparatus | COTE LAINEY BLAIR (US) | 2026-05-12 | — | — | US | claimed |
| US-12623828-B2 | Insulating container | YETI COOLERS, LLC (US) | 2026-05-12 | — | — | US | claimed |
| US-20260115145-A1 | Method for Enhancing Drug Solubility and Preparing a Drug Composite Material with Enhanced Solubility | PHARMAEASE TECH LTD (CN) | 2026-04-30 | — | — | US | claimed |
| US-20260116625-A1 | Liquid Pouring Apparatus | COTE LAINEY BLAIR (US) | 2026-04-30 | — | — | US | claimed |
| WO-2026087680-A1 | TREATMENT FOR CARDIOVASCULAR DISEASE | SAPREME TECHNOLOGIES B.V. (NL) | 2026-04-30 | — | — | WO | claimed |
| US-20260108482-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS INC (US) | 2026-04-23 | — | — | US | claimed |
| EP-0330532-A1 | New galenic form of fenofibrate | FOURNIER INDUSTRIE ET SANTE (FR) | 1989-08-30 | — | — | EP | claimed |
| US-4800079-A | ANTICHOLESTEROL, ANTILIPEMIC | U.S. BANK NATIONAL ASSOCIATION, IN ITS CAPACITY AS COLLATERAL AGENT | 1989-01-24 | — | — | US | claimed |
| EP-0286011-A2 | Natural pulmonary surfactant, method of preparation and pharmaceutical compositions | CHIESI FARMACEUTICI S.p.A. (IT) | 1988-10-12 | — | — | EP | claimed |
| US-4739101-A | Method for the preparation of fibrates | FOURNIER INNOVATION ET SYNERGIE (FR) | 1988-04-19 | — | — | US | claimed |
| EP-0256933-A1 | Process for preparation of a medicament based on fenofibrate and medicament obtained by this process | ETHYPHARM (FR) | 1988-02-24 | — | — | EP | claimed |
| EP-0245156-A1 | Preparation of fibrates | FOURNIER INNOVATION ET SYNERGIE (FR) | 1987-11-11 | — | — | EP | claimed |
| EP-0065531-A1 | NEW GALENIC PREPARATION OF PHENOFIBRATE, METHOD FOR THE OBTENTION THEREOF, ITS APPLICATION AS A MEDICINE | DESHORS (FR) | 1982-12-01 | — | — | EP | claimed |
| WO-1982001649-A1 | NEW GALENIC PREPARATION OF PHENOFIBRATE,METHOD FOR THE OBTENTION THEREOF,ITS APPLICATION AS A MEDICINE | LARUELLE CLAUDE | 1982-05-27 | — | — | WO | claimed |
| US-4250191-A | ADMINISTERING A PHENOXYACETIC ACID DERIVATIVE | EDWARDS K DAVID | 1981-02-10 | — | — | US | claimed |
| US-4058552-A | HYPOCHOLESTEROLEMIA, HYPOLIPIDEMIA | ORCHIMED SA (CH) | 1977-11-15 | — | — | US | claimed |