Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975565 | 0.88 | GSK3B (0.56) | GSK3BNR3C2HPGDKMT2APIM1 | |
| SCHEMBL2884894 | 0.88 | GSK3B (0.56) | GSK3BNR3C2HPGDKMT2APIM1 | |
| SCHEMBL2877773 | 0.84 | GSK3B (0.60) | GSK3BHPGDNOTUMPIM1PIM3 | |
| SCHEMBL12975564 | 0.84 | GSK3B (0.60) | GSK3BHPGDNOTUMPIM1PIM3 | |
| SCHEMBL6174177 | 0.80 | PIK3CG (0.55) | KMT2APIM1PIK3CGPIK3CARAB9A | |
| SCHEMBL2880312 | 0.78 | GSK3B (0.69) | GSK3BHPGDPIM1PIM3PIM2 | |
| SCHEMBL12975558 | 0.78 | GSK3B (0.69) | GSK3BHPGDPIM1PIM3PIM2 | |
| SCHEMBL6173813 | 0.76 | CSNK2A2 (0.59) | PIK3CGPIK3CANPC1RAB9A | |
| SCHEMBL6173818 | 0.76 | CSNK2A2 (0.59) | PIK3CGPIK3CANPC1RAB9A | |
| SCHEMBL6835907 | 0.75 | NAT1 (0.55) | NR3C2KMT2APIM1PIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931424-A2 | P13K INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | LABORATOIRES SERONO S.A. (CH) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007030360-A2 | P13K INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | LABORATOIRES SERONO S.A. (CH) | 2007-03-15 | — | — | WO | disclosed |