Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914975 | 0.81 | TSHR (0.33) | THRB | |
| SCHEMBL1007937 | 0.80 | — | — | |
| SCHEMBL27878310 | 0.78 | CHRM3 (0.30) | CHRM3PTPN1 | |
| SCHEMBL31685960 | 0.70 | — | — | |
| SCHEMBL29053129 | 0.69 | CA12 (0.33) | CHRM3PTPN1LMNACHRM2CHRM4 | |
| SCHEMBL29065453 | 0.68 | NPSR1 (0.38) | LMNA | |
| SCHEMBL1693381 | 0.66 | CHRM3 (0.35) | CHRM3PTPN1LMNACHRM2CHRM4 | |
| SCHEMBL11496766 | 0.65 | CHRM3 (0.37) | CHRM3PTPN1LMNACHRM2CHRM4 | |
| SCHEMBL1895595 | 0.65 | CHRM3 (0.32) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL3830377 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951676-A2 | LXR MODULATORS | Brystol-Myers Squibb Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007050425-A2 | LXR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-03 | — | — | WO | disclosed |