Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.66 |
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.59 |
| ▸ | GSK3A | P49840 | 3/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672944 | 0.84 | KDR (0.69) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4671969 | 0.79 | KDR (1.00) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4670133 | 0.79 | KDR (1.00) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4670496 | 0.78 | KDR (1.00) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4670122 | 0.77 | KDR (0.82) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4672132 | 0.76 | KDR (0.84) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4670094 | 0.76 | KDR (0.70) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL4672616 | 0.76 | KDR (1.00) | KDRBRAFFGFR2GSK3AGSK3B | |
| SCHEMBL1121940 | 0.76 | BRAF (1.00) | KDRBRAF | |
| SCHEMBL14017844 | 0.75 | KDR (0.64) | KDRBRAFFGFR2GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1330452-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002024681-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | disclosed |