⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468836 | 0.72 | — | — | |
| SCHEMBL20134678 | 0.72 | — | — | |
| SCHEMBL5846027 | 0.72 | — | — | |
| SCHEMBL11112992 | 0.72 | — | — | |
| SCHEMBL17295606 | 0.69 | — | — | |
| SCHEMBL2067649 | 0.69 | — | — | |
| SCHEMBL24521641 | 0.69 | — | — | |
| SCHEMBL2068644 | 0.69 | — | — | |
| SCHEMBL3518599 | 0.69 | — | — | |
| SCHEMBL2067621 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | Amgen Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| US-20060252777-A1 | Substituted heterocycles and methods of use | AMGEN INC. (US) | 2006-11-09 | — | — | US | claimed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | claimed |
| EP-3183237-B1 | PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES STARTING FROM HEXAFLUOROPROPENE | BAYER ANIMAL HEALTH GMBH (DE) | 2019-07-24 | — | — | EP | disclosed |
| EP-3148984-B1 | PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES STARTING FROM HEXAFLUOROPROPENE | BAYER ANIMAL HEALTH GMBH (DE) | 2019-07-24 | — | — | EP | disclosed |
| US-10059673-B2 | Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-08-28 | — | — | US | disclosed |
| US-9957256-B2 | Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-05-01 | — | — | US | disclosed |
| US-20170233348-A1 | Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene | ELANCO ANIMAL HEALTH GMBH (DE) | 2017-08-17 | — | — | US | disclosed |
| US-20170190690-A1 | Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene | ELANCO ANIMAL HEALTH GMBH (DE) | 2017-07-06 | — | — | US | disclosed |
| EP-3183237-A1 | PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES STARTING FROM HEXAFLUOROPROPENE | Bayer CropScience Aktiengesellschaft (DE) | 2017-06-28 | — | — | EP | disclosed |
| EP-3148984-A1 | PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES STARTING FROM HEXAFLUOROPROPENE | Bayer CropScience Aktiengesellschaft (DE) | 2017-04-05 | — | — | EP | disclosed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20050159438-A1 | Spirocyclic heterocyclic derivatives and methods of their use | ADOLOR CORPORATION | 2005-07-21 | — | — | US | disclosed |
| WO-2005033073-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
| EP-1417202-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| EP-1401826-A1 | PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-31 | — | — | EP | disclosed |
| US-20030069276-A1 | Amino piperidine derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | US | disclosed |
| US-6538015-B1 | Process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is | HOFFMANN-LA ROCHE INC. | 2003-03-25 | — | — | US | disclosed |
| WO-2002100853-A1 | PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002079186-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |