Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670302 | 0.90 | HRH3 (0.72) | HRH3KCNH2CYP3A4CYP2C9DRD2 | |
| SCHEMBL4670299 | 0.86 | HRH3 (0.64) | HRH3KCNH2CYP3A4CYP2C9DRD2 | |
| Hydrochloric Acid SCHEMBL5935439 | 0.85 | HRH3 (0.65) | HRH3KCNH2CYP3A4CYP2C9MAOB | |
| SCHEMBL4670300 | 0.85 | HRH3 (0.65) | HRH3KCNH2CYP3A4CYP2C9MAOB | |
| SCHEMBL4670297 | 0.84 | HRH3 (0.62) | HRH3KCNH2CYP3A4CYP2C9MAOB | |
| SCHEMBL4230533 | 0.81 | HRH3 (0.65) | HRH3DRD2 | |
| SCHEMBL4674376 | 0.80 | HRH3 (0.73) | HRH3KCNH2CYP3A4CYP2C9MAOB | |
| SCHEMBL4670679 | 0.80 | HRH3 (0.73) | HRH3KCNH2CYP3A4CYP2C9MAOB | |
| Hydrochloric Acid SCHEMBL4225310 | 0.80 | HRH3 (0.64) | HRH3DRD2 | |
| SCHEMBL4670379 | 0.79 | HRH3 (0.63) | HRH3KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1610786-B9 | 4-(4-(HETEROCYCLYLALKOXY PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER'S | GLAXO GROUP LTD (GB) | 2008-02-27 | — | — | EP | claimed |
| EP-1610786-B1 | 4-(4-(HETEROCYCLYLALKOXY PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER'S | GLAXO GROUP LTD (GB) | 2007-06-20 | — | — | EP | claimed |