⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618064 | 0.80 | — | — | |
| SCHEMBL8976771 | 0.78 | — | — | |
| SCHEMBL9182 | 0.78 | — | — | |
| SCHEMBL2183618 | 0.78 | — | — | |
| SCHEMBL147416 | 0.76 | — | — | |
| SCHEMBL16412155 | 0.74 | — | — | |
| SCHEMBL528162 | 0.72 | — | — | |
| SCHEMBL3770048 | 0.72 | — | — | |
| SCHEMBL1665187 | 0.72 | — | — | |
| SCHEMBL10606161 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007506661-A | — | — | 2007-03-22 | — | — | JP | claimed |
| CN-1812782-A | Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-02 | — | — | CN | claimed |
| EP-1638540-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-03-29 | — | — | EP | claimed |
| WO-2005000281-A2 | PYRAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS PLATELET AGGREGATION INHIBITORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-01-06 | — | — | WO | claimed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | claimed |
| CN-108329246-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2021-02-26 | — | — | CN | disclosed |
| US-10889589-B2 | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | ARRAY BIOPHARMA INC. (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190270749-A1 | BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN | ARRAY BIOPHARMA INC. (US) | 2019-09-05 | — | — | US | disclosed |
| US-10351575-B2 | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | ARRAY BIOPHARMA INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-10323022-B2 | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-06-18 | — | — | US | disclosed |
| US-20180334450-A1 | PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2018-11-22 | — | — | US | disclosed |
| CN-103804341-B | Amide derivatives and its medical usage | 中国人民解放军军事医学科学院毒物药物研究所 | 2018-04-10 | — | — | CN | disclosed |
| CN-1399622-A | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | HORMOS MEDICAL OY LTD (FI) | 2003-02-26 | — | — | CN | disclosed |
| EP-0833628-A4 | NOVEL TAXOIDS | BIOPHYSICA INC (US) | 2002-05-02 | — | — | EP | disclosed |
| CN-1329605-A | Benzofuran derivatives their preparation and use | LUNDBECK & CO AS H (DK) | 2002-01-02 | — | — | CN | disclosed |
| WO-2001056358-A2 | ENHANCED PROPERTIED PESTICIDES | ROHM AND HAAS COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |
| EP-0833628-A1 | NOVEL TAXOIDS | BIOPHYSICA FOUNDATION (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996038138-A1 | NOVEL TAXOIDS | BIOPHYSICA FOUNDATION (US) | 1996-12-05 | — | — | WO | disclosed |
| US-4187234-A | FIRBRINOLYTIC AND THROMBOLYTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1980-02-05 | — | — | US | disclosed |