Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249032 | 0.81 | GRM4 (0.57) | GRM4HPGDALDH1A1MAPTADORA3 | |
| SCHEMBL14947687 | 0.80 | CCNE1 (0.47) | HPGDEGFRALDH1A1CCNE1CDK2 | |
| SCHEMBL4677393 | 0.77 | GRM4 (0.52) | GRM4HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18626100 | 0.77 | BRAF (0.41) | BRAFDYRK1ADYRK2DYRK1B | |
| SCHEMBL4671104 | 0.75 | CDK2 (0.52) | GRM4HPGDEGFRJAK3MAPK10 | |
| SCHEMBL3575717 | 0.74 | BPTF (0.43) | SMN1; SMN2ALDH1A1MAPTLMNAHTT | |
| SCHEMBL4447801 | 0.72 | BPTF (0.54) | HPGDSMN1; SMN2EGFRCYP3A4BRAF | |
| SCHEMBL8242894 | 0.71 | DYRK1B (0.36) | EGFRCYP3A4BRAFJAK3MAPK10 | |
| SCHEMBL6070872 | 0.70 | MDM2 (0.40) | HPGDEGFRCYP3A4BRAFJAK3 | |
| SCHEMBL29126610 | 0.69 | KDM4C (0.45) | HPGDSMN1; SMN2ALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343781-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1343781-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2003-09-17 | — | — | EP | disclosed |
| US-20020111353-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2002-08-15 | — | — | US | disclosed |
| WO-2002046184-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111353-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | MAPK1, MAPK3, MAPKAPK3 | GRM4 2990/4885HPGD 1865/4885SMN1; SMN2 1206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.