Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 12/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19810785 | 0.88 | PTGER4 (0.53) | ABCB1HTR1ADRD2RAB9AAPEX1 | |
| SCHEMBL5685633 | 0.87 | ABCB1 (0.58) | ABCB1HTR1ADRD2RAB9AABCG2 | |
| SCHEMBL11688092 | 0.86 | PTGER4 (0.54) | ABCB1HTR1ADRD2RAB9AAPEX1 | |
| SCHEMBL17978208 | 0.85 | APEX1 (0.56) | RAB9AAPEX1 | |
| SCHEMBL7492550 | 0.85 | ABCB1 (0.49) | ABCB1HTR1ADRD2RAB9AABCG2 | |
| SCHEMBL5333596 | 0.84 | USP2 (0.61) | ABCB1RAB9AFABP4 | |
| SCHEMBL7440994 | 0.83 | ABCB1 (0.53) | ABCB1HTR1ADRD2RAB9AABCG2 | |
| SCHEMBL3563734 | 0.82 | AKR1C3 (0.53) | — | |
| SCHEMBL2628165 | 0.81 | FOLH1 (0.51) | RAB9A | |
| SCHEMBL11710019 | 0.81 | HTT (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218405-B | The synthesis technique of (R, S) 2 [[base of 5 (9 fluorenylmethyloxycarbonyl amino) dibenzo [A, D] cycloheptane 2] oxygen] acetic acid | 上海泰坦科技股份有限公司 | 2017-07-28 | — | — | CN | claimed |
| CN-104761470-B | The preparation method of (R, S)-2-[[5-(9-fluorenylmethyloxycarbonyl amino) dibenzo [a, d] cycloheptane-2-base] oxygen] acetic acid | 吉尔生化（上海）有限公司 | 2016-08-24 | — | — | CN | claimed |
| CN-105218405-A | The synthesis technique of (R, S)-2-[[5-(9-fluorenylmethyloxycarbonyl is amino) dibenzo [A, D] suberane-2-base] oxygen] acetic acid | SHANGHAI TITAN TECHNOLOGY CO LTD | 2016-01-06 | — | — | CN | claimed |
| CN-104761470-A | Preparation method of (R,S)-2-[[5-(9-fluorenemethoxycarbonylamino)dibenzo[A,D]cycloheptane-2-yl]oxyl]acetic acid | GL BIOCHEM SHANGHAI CO LTD | 2015-07-08 | — | — | CN | claimed |
| CN-117510323-B | Preparation method of Ramage Linker intermediate | 成都泰莱康科技有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117510323-B | Preparation method of Ramage Linker intermediate | 成都泰莱康科技有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117510323-A | Preparation method of Ramage Linker intermediate | 成都泰莱康科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-117510323-A | Preparation method of Ramage Linker intermediate | 成都泰莱康科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-105218405-B | The synthesis technique of (R, S) 2 [[base of 5 (9 fluorenylmethyloxycarbonyl amino) dibenzo [A, D] cycloheptane 2] oxygen] acetic acid | 上海泰坦科技股份有限公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-104761470-B | The preparation method of (R, S)-2-[[5-(9-fluorenylmethyloxycarbonyl amino) dibenzo [a, d] cycloheptane-2-base] oxygen] acetic acid | 吉尔生化（上海）有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105218405-A | The synthesis technique of (R, S)-2-[[5-(9-fluorenylmethyloxycarbonyl is amino) dibenzo [A, D] suberane-2-base] oxygen] acetic acid | SHANGHAI TITAN TECHNOLOGY CO LTD | 2016-01-06 | — | — | CN | disclosed |
| CN-104761470-A | Preparation method of (R,S)-2-[[5-(9-fluorenemethoxycarbonylamino)dibenzo[A,D]cycloheptane-2-yl]oxyl]acetic acid | GL BIOCHEM SHANGHAI CO LTD | 2015-07-08 | — | — | CN | disclosed |
| EP-1216994-B1 | Tricyclic antidepressant derivatives and immunoassay | ROCHE DIAGNOSTICS GMBH (DE) | 2008-12-31 | — | — | EP | disclosed |
| EP-1216994-A2 | Tricyclic antidepressant derivatives and immunoassay | Roche Diagnostics GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| US-6368814-B1 | TRICYCLIC ANTIDEPRESSANTS AND METABOLITES THEREOF | ROCHE DIAGNOSTICS CORPORATION | 2002-04-09 | — | — | US | disclosed |
| EP-0075698-B1 | PROCESS FOR THE PREPARATION OF 10,11-DIHYDRO-5H-DIBENZO(A,D) CYCLOHEPTEN-5-ON AND ITS SUBSTITUTION PRODUCTS | HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) | 1986-01-02 | — | — | EP | disclosed |
| US-4560787-A | CYCLOCONDENSATION, ACID CATALYSTS, TRICHLOROMETHYL BENZENE | DYNAMIT NOBEL AG (DE) | 1985-12-24 | — | — | US | disclosed |
| EP-0115690-A1 | Dibenzocycloheptenylidenes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-15 | — | — | EP | disclosed |
| US-4399141-A | 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof | MERCK & CO., INC. (US) | 1983-08-16 | — | — | US | disclosed |
| EP-0075698-A2 | Process for the preparation of 10,11-dihydro-5H-dibenzo(a,d) cyclohepten-5-on and its substitution products | HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) | 1983-04-06 | — | — | EP | disclosed |