Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22439633 | 0.86 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL2270899 | 0.86 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL5792377 | 0.82 | SLC6A4 (0.63) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL7484043 | 0.81 | SLC6A4 (0.65) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL9093624 | 0.81 | HTR1B (0.66) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL7479378 | 0.81 | SLC6A4 (0.65) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL8304104 | 0.81 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| Ethylene SCHEMBL7484426 | 0.80 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6342362 | 0.79 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL8103895 | 0.79 | SLC6A4 (0.69) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |