Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.59 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.44 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670488 | 0.89 | PTPN1 (0.73) | PTPN1THRATHRBNR1H4SIRT3 | |
| SCHEMBL4670720 | 0.86 | PTPN1 (0.58) | PTPN1THRATHRBNR1H4SIRT3 | |
| SCHEMBL4670211 | 0.82 | PTPN1 (0.63) | PTPN1THRATHRBNR1H4SIRT3 | |
| SCHEMBL3971361 | 0.82 | PTPN1 (0.54) | PTPN1THRATHRBNR1H4SIRT3 | |
| SCHEMBL4670382 | 0.81 | PTPN1 (0.59) | PTPN1 | |
| SCHEMBL4672989 | 0.80 | PTPN1 (0.59) | PTPN1 | |
| SCHEMBL4673205 | 0.80 | NR1H4 (0.40) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4673820 | 0.80 | PTPN1 (0.53) | PTPN1NR1H4SIRT3 | |
| SCHEMBL4670406 | 0.80 | PTPN1 (0.53) | PTPN1NR1H4SIRT3 | |
| SCHEMBL7038911 | 0.79 | PTPN1 (0.43) | PTPN1NR1H4SIRT3EYA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |