Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | UTRN | P46939 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676381 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL29479840 | 0.77 | PIK3CB (0.57) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL2247599 | 0.76 | NPC1 (0.62) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL1675431 | 0.74 | KDM4E (0.54) | KDM4EHPGDS1PR1S1PR3HDAC6 | |
| SCHEMBL13528498 | 0.74 | NPC1 (0.72) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL26928757 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL38661261 | 0.73 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL7905531 | 0.73 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL2244575 | 0.73 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AKDM4EHPGD | |
| SCHEMBL12171676 | 0.73 | S1PR1 (0.48) | SMN1; SMN2NPC1RAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |