Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 5/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678044 | 1.00 | IRAK4 (0.40) | IRAK4PDE4DSYKPDE4APDE4B | |
| SCHEMBL4268986 | 0.87 | IRAK4 (0.44) | IRAK4SYKNPC1RAB9AJAK2 | |
| SCHEMBL4268979 | 0.87 | IRAK4 (0.44) | IRAK4SYKNPC1RAB9AJAK2 | |
| SCHEMBL4278914 | 0.87 | IRAK4 (0.44) | IRAK4SYKNPC1RAB9AJAK2 | |
| SCHEMBL4279736 | 0.78 | IRAK4 (0.49) | IRAK4SYKNPC1RAB9AJAK2 | |
| SCHEMBL13608563 | 0.75 | IRAK4 (0.45) | IRAK4NPC1RAB9AIRAK1RXFP1 | |
| SCHEMBL4276003 | 0.75 | IRAK4 (0.45) | IRAK4NPC1RAB9AIRAK1RXFP1 | |
| SCHEMBL4269959 | 0.75 | CACNB4 (0.40) | IRAK4SYKNPC1RAB9AJAK2 | |
| SCHEMBL4272904 | 0.75 | CACNB4 (0.40) | IRAK4SYKNPC1RAB9AJAK2 | |
| SCHEMBL4269962 | 0.75 | CACNB4 (0.40) | IRAK4SYKNPC1RAB9AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644334-B1 | ANTITHROMBOTIC ETHERS | LILLY CO ELI (US) | 2008-01-02 | — | — | EP | disclosed |