Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174550 | 0.88 | PDE4B (0.64) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL1652433 | 0.87 | PDE4B (0.66) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL3028488 | 0.87 | PDE4B (0.60) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL3032844 | 0.82 | PDE4B (0.66) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL4705603 | 0.81 | PDE4B (0.69) | PDE4BSMN1; SMN2TP53PDE4APDE4C | |
| SCHEMBL4708015 | 0.81 | PDE4B (0.65) | PDE4BSMN1; SMN2TP53 | |
| SCHEMBL4707277 | 0.81 | PDE4B (0.67) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL4708773 | 0.81 | PDE4B (0.67) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL4707690 | 0.81 | PDE4B (0.70) | PDE4BADORA3ADORA1SMN1; SMN2TP53 | |
| SCHEMBL4706432 | 0.81 | PDE4B (0.67) | PDE4BADORA3ADORA1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | claimed |