Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29928369 | 0.89 | TP53 (0.72) | POLBBLMTDP1TP53MAPT | |
| SCHEMBL4581685 | 0.89 | TP53 (0.72) | POLBBLMTDP1TP53MAPT | |
| SCHEMBL4581652 | 0.82 | TP53 (0.70) | TP53MAPTKMT2ATSHRLMNA | |
| SCHEMBL1790357 | 0.81 | TP53 (1.00) | TDP1TP53MAPTKMT2ATSHR | |
| SCHEMBL4581758 | 0.81 | TP53 (0.82) | POLBTDP1TP53MAPTKMT2A | |
| SCHEMBL4211625 | 0.80 | USP2 (0.62) | TP53MAPTKMT2ATSHRLMNA | |
| SCHEMBL4592430 | 0.80 | TP53 (0.87) | POLBTDP1TP53MAPTKMT2A | |
| SCHEMBL4582080 | 0.80 | TP53 (0.72) | POLBTP53MAPTKMT2ATSHR | |
| SCHEMBL15677935 | 0.79 | TP53 (0.56) | TP53MAPTKMT2ATSHRLMNA | |
| SCHEMBL4582538 | 0.79 | TP53 (0.71) | POLBTP53MAPTKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663204-A4 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1663204-A2 | C-KIT MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005020921-A2 | C-KIT MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |