Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499502 | 0.86 | POLB (0.47) | SYKPOLBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19456479 | 0.86 | POLB (0.47) | SYKPOLBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30307663 | 0.86 | POLB (0.47) | SYKPOLBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30878162 | 0.86 | POLB (0.47) | SYKPOLBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23491355 | 0.81 | SYK (0.45) | SYKPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30447863 | 0.81 | NPSR1 (0.45) | SYKPOLBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23491247 | 0.81 | SYK (0.45) | SYKPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30447288 | 0.81 | NPSR1 (0.45) | SYKPOLBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30447697 | 0.80 | NPSR1 (0.44) | SYKPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL30447606 | 0.80 | NPSR1 (0.44) | SYKPOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045836-B1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1171113-B1 | COMPOUNDS USEFUL AS PHOSPHOTYROSINE MIMICS | BOEHRINGER INGELHEIM PHARMA (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1171113-A1 | COMPOUNDS USEFUL AS PHOSPHOTYROSINE MIMICS | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6284768-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| US-6268365-B1 | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-07-31 | — | — | US | disclosed |
| US-6156784-A | Compounds useful as phosphotyrosine mimics | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| WO-2000062770-A1 | COMPOUNDS USEFUL AS PHOSPHOTYROSINE MIMICS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-10-26 | — | — | WO | disclosed |
| EP-1045836-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-6054470-A | Src family SH2 domain inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999031066-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |