Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.35 |
| ▸ | SMO | Q99835 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 5/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930868 | 1.00 | KDR (0.35) | KDRSMOKDM4EHSD17B10FLT1 | |
| SCHEMBL1931638 | 0.87 | KDR (0.41) | KDRFLT1PDGFRBKITMEN1 | |
| SCHEMBL4834682 | 0.85 | CYP11B1 (0.31) | — | |
| SCHEMBL4679265 | 0.84 | KDM4E (0.40) | KDRSMOKDM4EHSD17B10FLT1 | |
| SCHEMBL1931665 | 0.84 | KDM4E (0.40) | KDRSMOKDM4EHSD17B10FLT1 | |
| SCHEMBL4740445 | 0.83 | KDR (0.33) | KDRSMOFLT1PDGFRBKIT | |
| SCHEMBL4740449 | 0.83 | KDR (0.33) | KDRSMOFLT1PDGFRBKIT | |
| SCHEMBL1929839 | 0.71 | KDR (0.42) | KDRKDM4EHSD17B10FLT1PDGFRB | |
| SCHEMBL4681363 | 0.69 | KDR (0.42) | KDRKDM4EHSD17B10FLT1PDGFRB | |
| SCHEMBL1930948 | 0.69 | KDR (0.42) | KDRKDM4EHSD17B10FLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1387836-B1 | PHTHALAZINE DERIVATIVES WITH ANGIOGENESIS INHIBITING ACTIVITY | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |